Dangers of Arthritis Medication for Dogs

Dangers of Arthritis Medication for Dogs

Posted by Bill Gluyas on 27th Aug 2023

Vetprofen 100mg, Rimadyl long-term, the cheapest Meloxicam… What is your next search term to help your arthritic dog?

Vetprofen 100mg, Rimadyl long-term, the cheapest Meloxicam… The group name is NSAIDs (Nonsteroidal anti-inflammatory drugs).

And since you are looking for these, I guess, your pal is in trouble?!

Before going any further with your research, try to gather all the facts about, i.e., Vetprofen 100mg.

Yes, NSAIDs control signs of arthritis, including inflammation, swelling, stiffness, and joint pain. Inflammation—the body’s response to irritation or injury—is characterized by redness, warmth, swelling, and pain. NSAIDs mediate the production or function of prostaglandins (enzymes) involved in inflammation. Read More

But what is the actual cost?

I am not talking about the money when I ask what is the cheapest solution?

What does Vetprofen 100mg do for dogs?

Rimadyl, Novox, and Vetprofen are brand names of Carprofen specially formulated for dogs.

Pfizer Animal Health created and released this drug for dogs in 1997 in the USA to answer the need for a safe medication only for dogs. For example, Rimadyl is the number 1 osteoarthritis drug veterinarians prescribe for pain and inflammation relief in canines.

It is a nonsteroidal anti-inflammatory drug used by veterinarians to relieve short-term postoperative pain, inflammation, and swelling.

Is Vetprofen 100mg the same as Ibuprofen?

Vetprofen (carprofen) 100 mg relieves pain and inflammation associated with degenerative joint diseases like osteoarthritis or hip dysplasia in dogs. It is a non-steroidal anti-inflammatory drug (NSAID) in the same class as ibuprofen, naproxen, and ketoprofen.


Do not under any circumstances give ibuprofen to your dog or cat.

Ibuprofen is a common and effective medication used to treat inflammation and pain in humans, but you should not give it to pets. These medications can be poisonous to dogs and cats.

Will one Ibuprofen kill my dog?

Dogs are extremely sensitive to the harmful effects of this class of drugs, called nonsteroidal anti-inflammatory drugs, and ibuprofen is one of the worst offenders. Its ingestion causes kidney failure in dogs and cats. Even one large dose is enough.


What if you already gave your dog Ibuprofen?

I would call a vet immediately.

Ibuprofen is toxic to dogs, especially for the small breed. So please don’t wait. It’s not worth the risk. It’s better to pay a small, unnecessary vet bill than to wait and pay a ridiculously high one involving intensive care.

Yes, there are ‘profens’ for human and dog use, but they kinda act the same.

NSAIDs are anti-inflammatory drugs. And inflammation is an immune response and damage control system in the body.

The affected area (such as a wound or a bacterial infection) widens its arteries (where blood travels from the heart). But, at the same time, it constricts its veins to allow more blood to rush to the area and temporarily stay there.

To put it as simply as possible, this means that, if infected, white blood cells can get to an infected area and help fight the infection, and red blood cells can help carry the necessary nutrients to help the body repair itself. So basically, inflammation is crucial in the body to heal injuries and fight infection, but the process can lead to heat, swelling, and painful sensations.

So, what happens when you take NSAIDs or give NSAIDs for pets to your dog?

It basically tries to reverse the effects of inflammation by widening veins to allow some of the blood in the area to be released. This alleviates swelling and pain but can also hinder the speed that the body heals and recovers, especially if overused.

Like most drugs, overuse can be very bad for your kidneys over time, as the chemical has to be constantly filtered out of the bloodstream.

The liver releases enzymes to help in this, damaging the liver if overused. In addition, increased blood pressure is associated with long-term use, leading to hypertension, heart disease, and gastrointestinal issues.

The most common problems that arise from long-term NSAID (Vetprofen 100mg) use

The most common problem from long-term NSAID (Vetprofen 100mg) use is stomach irritation and bleeding.

NSAIDs have an anti-inflammatory effect by modifying inflammatory reactions. They exhibit help by relieving certain types of pain. They also reduce fever.

These drugs make their effort by inhibiting arachidonic cyclooxygenase. In a manner like this, it prevents the production of prostaglandins and thromboxanes that participate in inflammatory processes.

This is an inflammatory process that your body needs there for some time, to heal properly.

There are three types of cyclooxygenase enzymes: COX-1, COX-2, and COX-3.

COX-1 is present in most tissues, including platelets. It has a supervisory role in the body and is involved in homeostasis processes.

COX-2 is induced in inflammatory cells when they are in a state of activation, and in this case, inflammatory cytokines – interleukin-1 (IL-1)

Therefore, cyclooxygenase-2 is responsible for the production of inflammatory mediators. In addition to this role, COX-2 is also found in the central nervous system (CNS). It has a vital role in blood flow through the kidneys.

Prostaglandins also have a role to protect the stomach lining from acid erosion.

And most nonsteroidal anti-inflammatory drugs inhibit both COX-1 and COX-2. Unfortunately, this leads to unwanted effects, e.g., in the digestive tract due to stopping COX-1.

However, your vet will probably say that newer generations are selective and act mainly on COX-2. Therefore, they have fewer side effects.

The mechanism isn’t important here, but this effect is of concern if you want longevity for your furry pal.

If your pet has already taken one NSAID, using another NSAID is VERY dangerous.

You need to have what’s known as a washout period. Depending on the NSAID, they have different washout periods. Giving two separate NSAIDs with different direct mechanisms of action can compound the negative side effects (i.e., COX-1 inhibition, which first leads to stomach ulcers).

But there are worse things. For example, the US FDA has forced the manufacturers of Rimadyl to carry a label warning that it could cause death in dogs.

What about the long-term effect of Vetprofen 100mg and other NSAIDs?

Well, I have found a study that shows testimonials of owners of different breeds in Great Britain. But also testimonials of their vets.

The study showed their experience with NSAIDs.

While short-term administration of NSAIDs to dogs is linked to adverse events such as gastrointestinal bleeding and renal injury, reports of adverse events associated with long-term administration are limited in the veterinary literature.

Veterinary surgeons had problems recognizing, managing, and avoiding negative events associated with NSAIDs. As a result, when side effects occurred, they pulled back the administration of NSAIDs to that dog.

The inclusion criteria for interviewees were:

a) ownership of a dog currently treated or managed for osteoarthritis affecting at least one limb due to any underlying etiology;

b) ownership of a dog at least five years of age at the time of the interview; AND

c) the owner(s) and the dog(s) must live in the United Kingdom.

All interviews captured the views of 40 owners of 35 dogs with osteoarthritis treated at seventeen different veterinary practices.

All dogs had received at least one of five different NSAIDs (carprofen, cimicoxib, firocoxib, meloxicam, robenacoxib) for their osteoarthritis. Although, with no direct source of info, owners were aware of one or more “side effects” associated with using NSAIDs in dogs.

A few owners had been told about adverse events associated with NSAIDs affecting friends’ dogs. And a couple had experienced adverse events with previous dogs.

They were most concerned about organ damage and gastro issues (vomiting, diarrhea, and ulceration).

Several owners described finding websites that alarmed them, particularly regarding reports of carprofen-related deaths. A few expressed their shock that a veterinary surgeon prescribed a drug associated with death, though many knew they should not trust everything they read on the internet.

One owner said:

“No, I’m not aware of any side effects [associated with carprofen]. I think if there were side effects [my vet] would tell me, so I tend not to Google dogs.” [Owner 30]

Some owners reported that their dog had experienced one or more episodes of gastroenteritis while receiving an NSAID. Typically this involved vomiting with or without blood and/or diarrhea containing fresh blood or melena.

Another owner said:

“She started on Previcox. And that gave her a bleed … Yeah, her poos suddenly came full of blood. I stopped it immediately, took her back [to the vets], gave her a break, and then changed her to Rimadyl, and she’s been okay on that ever since.” [Owner 16]

And owner number 7 said:

“About three months later, because they’re monitoring her regularly, [her liver values had] gone down again, then they went up again, then they’d gone down again, so we’d decided that she’s just erratic. But the vet said, “Oh dear, we’d better have a biopsy.” and all the rest of it. Ooh! Panic! It was very expensive…

I’m glad we did it because we ruled out she hadn’t got cancer or anything. But I still don’t know whether the Rimadyl pushed her up a bit.”

Many veterinary surgeons associated adverse events with poor owner compliance, citing examples of incorrect dosing, the drugs being given without food, or continued administration to an ill dog as common causes.

And why would they tell it differently? They learned through the end of college to protect BIG Pharma and serve them (not dog owners).

“I’m absolutely anti-Rimadyl. It’s on my notes that I never, ever give my dogs Rimadyl. And then when I find they’ve had Rimadyl, I go mad. My parents’ cocker spaniel died of platelet eruption on Rimadyl at seven… It might be good pain relief, but I will not have it.” [Owner 3]

The study showed that owners are not satisfied with the information provided by their veterinary surgeons, so they seek additional guidance.

However, trustworthy sources may be challenging to find.

The results above you should not interpret as representative opinions of all dog owners or veterinary professionals in the United Kingdom. They should only show you that being concerned about NSAIDs is not just in your mind.

The findings of this study should be of value to anyone interested in improving the general condition of a dog with any bone disorder. Read More


You can keep your dog as comfortable as possible by placing a soft bed or couch with fluffy blankets for him to lie on.

Treat your dog to a luxurious massage, his favorite toys, and his favorite food. However, do not forget to provide your dog with a balanced diet to be as healthy as possible during the condition.


Diseases of the locomotor system, especially joints, are among the most common causes of visits to veterinary clinics. The development of joint diseases is most often a consequence of improper or excessive animal loading, repeated microtraumas, constant stereotypical stress on the joints, congenital or acquired joint damage, aging, and nutrition without enough nutrients for joint cartilage.

One thing that you can try is deer antler velvet for dogs – a supplement containing many natural ingredients that complement bone/joint disorders in dogs. And when I say ingredients, I mean: Proteins and Growth Factors, Glycosaminoglycans(GAGs), Lipids, Minerals, and Trace elements.

There is simply no other supplement – natural or synthetic that can replicate the compounds present in total balance as are in velvet antler. And it has no long-term or any other side effects.

You can find more about this natural supplement for dogs here.

In the end …

I think it is best to avoid medicating a pet except in extreme circumstances because they cannot share (1) whether the medication works or (2) whether they are experiencing adverse side effects.

That said if you choose to give your dog medication, research side effects and how to notice them.

When the doctor prescribes a medicine for your dog, you should receive a four-page, small-print document describing the medication, what it is used for, and possible side effects. Unfortunately, most people ignore those and only refer to them if they feel strange side effects. If you go to a vet, it is very rare to receive a list of side effects and how to identify them.

I know one person who almost lost her dog because the vet prescribed a pain medication that affected balance to the point that she had a fall resulting in spinal damage.

The dog was paralyzed after that and never recovered. I’m not telling you this to scare you away from going to the vet, but to be aware and not lazy.

You are committed to helping your furry little friend, and you should be. However, you should be flexible in your approach.

Please share this with your social media contacts or anyone whose dog you think could benefit from Superflex-V

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